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Pharma Excipient Silicon Dioxide

Application:Pharma-grade silicon dioxide prepared through advanced processes, appearing as a white, loose powder. The product features a core nano-network structure, offering advantages such as uniform particle size, excellent dispersibility, and strong chemical stability. It does not react with active pharmaceutical ingredients. With its high specific surface area and strong inter-particle interactions, serves as a key pharmaceutical excipient to enhance the quality and stability of drug formulations. Our pharma grade silica  use in pharmaceuticals, food, feed, and related fields, while supporting customized performance solution

CAS.NO.: 7631-86-9

Mesh Size: 2-50μm (customizable)

HS CODE: 2811229000

Standard: GB 25576, USP, FCC, FDA

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Application Fields

4.1 Solid dosage forms
Tablets, capsules, and powders: These can be uniformly dispersed using standard mixing equipment. The system acts as a barrier to reduce inter-particle interactions, improves free flowability, and prevents caking. It accelerates tablet compression speed while optimizing production processes for smooth powder transportation. The adsorbent/water-absorbing material effectively controls moisture and liquid content (conversion rate depends on dosage). This reduces compatibility issues between pharmaceutical components, promotes uniform distribution of powder constituents, and enhances tablet disintegration speed.

•Tablet/capsule: Add 0.1-0.5% as a flow aid, which can reduce the powder resting angle by 20-30%, reduce the weight difference in the tablet process, and improve the hardness of tablets by 15-20% and reduce the brittleness.

•Direct tablet process: optimize material flow, reduce the amount of lubricant, shorten the production cycle, suitable for acetaminophen, aspirin and other API systems.

4.2 Liquid preparations

Pharmaceutical liquids (gels, creams, suspensions, etc.): Viscosity varies with shear rate, enabling thickening into paste or thinning for easy application. Prevents hard precipitation, sedimentation, and streaking while enhancing gel transparency and raw material distribution uniformity. Improves suspension stability and prevents aerosol sedimentation (requires high-shear equipment for thorough dispersion to achieve optimal performance).

•Oral suspension: As a suspending agent and thickener, the addition of 0.5-2.0% can make the sediment volume ratio of API> 95%, prevent drug stratification, and improve the dosage accuracy.

•Injections/eye preparations: in line with IPEC-GMP sterile production standards, can enhance the stability of the solution, reduce the risk of particle generation, and adapt to the needs of sensitive liquid preparations.

4.3 Nutritional supplements

•Active ingredient carrier: adsorb vitamins, probiotics and other ingredients to extend the shelf life of products and increase the retention rate of biological activity by more than 30%, suitable for protein powder, nutritional powder and other products.

•Anti-caking agent: in the environment of humidity ≤60%, the powder material can be kept for more than 6 months without lumping to ensure the fluidity of the product.

4.4 Food applications:

As a direct food additive, it enhances the flowability of food powders (including soft organic powders), prevents storage caking while maintaining dryness; adsorbs moisture, suitable for damp/hygroscopic powders; serves as a thickener for liquid foods like pickling juices and vegetable oils, and acts as a thixotropic agent in oil-based baking and cooking sprays; additionally optimizes equipment cleanliness during raw material grinding processes.

4.5 Application in feed field:

Optimize feed performance and processing technology to ensure the free flow and storage resistance of supplement powder, and give good moisture adjustment properties to particles; optimize grinding and milling process to prevent product from sticking to equipment.


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